Contraindicated (1)pentobarbital will lessen the extent or outcome of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Lack of, or lowered reaction to tofacitinib may manifest when c